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Phenytoin, Sodium Valproate, Valproic Acid. The result of barbiturates on the metabolism of phenytoin seems being variable. Some investigators report an accelerating influence, whereas Some others report no effect. Because the outcome of barbiturates on the metabolism of phenytoin is not predictable, phenytoin and barbiturate blood levels should be
phenobarbital will reduce the level or impact of ombitasvir/paritaprevir/ritonavir & dasabuvir (DSC) by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Powerful CYP3A4 inducers may well reduce partiaprevir and ritonavir levels, and thus lessened efficacy of Viekira PakContraindicated (one)phenobarbital will lower the level